Cognitive profile of patients with drug-resistant epilepsy based on clinical variability

Document Type : Original Article

Authors

1 Department of Psychology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili

2 Professional doctorate student, Department of Medicine, Faculty of Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.

Abstract

The present research was conducted with the aim to examine the relationship between clinical variables of epilepsy and cognitive disorders of patients with drug-resistantepilepsy(DRE). From among patients with DRE who had a medical record in Ardabil Welfare Organization, Ardabil, Iran, 35 participants aged between 20 and 35 years old, filled out the questionnaire related to demographic and clinical variables in the summer of 2017. Furthermore, to examine cognitive performance, the Rey-Osterrieth complex figure test and Wisconsin Card Sorting Test were employed. Patients who had emotional turmoil scores higher than 28 (cut-off point) were excluded from the study. Data were analyzed using correlation test and simultaneous regression analysis in SPSS software. The results revealed a significant correlation between clinical variables and cognitive performance. Additionally, based on the obtained regression coefficients, disease duration (p = 0.35) did not have a significant role in predicting memory performance. However, seizure frequency (p = 0.01), number of anti-epileptic drugs (AEDs) consumed (p = 0.03), and age at the onset of seizure (p = 0.01) had significant roles in predicting the memory performance. The results also revealed that disease duration (p = 0.47), seizure frequency (p = 0.70), and age at the onset of seizure (p = 0.06) had no significant role in predicting the executive function. Nevertheless, the number of AEDs consumed (p = 0.02) had a significant role in predicting the executive function. Clinical factors of epilepsy had a role in predicting cognitive performance of the patients

Keywords

References

Alessio, A., Damasceno, B. P., & Camargo, C. H. P. (2004). Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy. Epilepsy Behavior, 5, 22-27. doi :10.101 10.101 6ana.1874.
Begley, C. E., Famulari, M., Annegers, J. F., Lairson, D. R., Reynolds, T. F., Coan, S., Dubinsky S., Newmark, M. E., & Leibson, C. (2000). Evaluation and management of drug-resistant epilepsy. Epilepsia, 41, 342–351. doi: 10.1016/j04224.
Cendes, F., Sakamoto, A. C., & Spreafico, R. (2014). Epilepsies associated with hippocampal sclerosis. Acta Neuropathologica, 128, 21–37. doi: 10.1007/s00401-014-1292-0.
Eddy, C. M., Rickards, H. E., & Cavanna, A. E.(2011). The cognitive impact of antiepileptic drugs. Therapeutic Advances in Neurological Disorders, 4, 385–407. doi: 10.1177/1756285611417920.
Fuerst, D., Shah, J., Shah, A., & Watson, C. (2003). Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study. Annals of Neurology, 53, 413–416. doi: 10.1002/ana.10509. 
Hamed, S. A. (2009). The aspects and mechanisms of cognitive alterations in epilepsy: The role of antiepileptic medications. CNS Neuroscience & Therapeutic, 15,134–156. doi: 10.1111/j.1755-5949.
Helmstaedter, C., Kurthen, M., & Lux, S. (2003). Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy., Annals of Neurology, 54, 425–432. doi:  10.1002/ana.10692. Hendriks, M. P. H., Aldenkamp, A. P., & Alpherts, W. C. J. (2004). Relationships between epilepsy-related factors and memory impairment. Acta Neuropathologica, 110, 291–300. doi: 10.1111/j.1600-0404. Hermann, B., Jones, J., & Sheth, R. (2006). Children with new-onset epilepsy: Neuropsychological status and brain structure. Brain, 129, 2609–2619. doi: 10.1093bra1968. 
Hermann, B. P., Seidenberg, M., & Bell, B. (2002). The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects. Progress in Brain Research, 135, 429–438. doi: 10.1016/S0079-6123(02)35040-4.
Kleen, J. K., Scott, R. C., & Holmes, G. L. l. (2013). Hippocampal interictal epileptiform activity         disrupts cognition in humans. Neurology ,81, 18–24. doi: 10.1212/WNL.18297.
Kwan, P., & Brodie, M. J. (2001). Neuropsychological effects of epilepsy and antiepileptc drugs. Neurology, 357, 216–222. 10.1212/con0297
Lah, S., Lee, T., Grayson, S., & Miller, L. (2006). Effects of temporal lobe epilepsy on retrograde memory. Epilepsia, 47, 615–625. doi: 10.1111/j.1528.
Lenck-Santini, P. P., & Scott, R. C. (2015). Mechanisms responsible for cognitive impairment in epilepsy. Perspectives in Medicine, 2, 34-40. doi: 10.1101/cshperspect. a022772
López González, F. J., Osorio, X., & Gil-Nagel Rein, A. (2015). Drug-resistant epilepsy Definition and treatment alternatives. Neuroogyl, 30, 439–446. doi: 10.1016/j. nrleng4023. Mazur-Mosiewicz, A., Carlson, H. L., & Hartwick, C. (2015). Effectiveness of cognitive rehabilitation following epilepsy surgery: Current state of knowledge. Epilepsia, 56,735–744. doi: 10.1111/epi.12963.
Miller, L. A., Galioto, R., & Tremont, G. (2016). Cognitive impairment in older adults with epilepsy: Characterization and risk factor analysis. Epilepsy Behavior, 56,113–117. doi: 10.1016/j1011.
Mohanraj, R. (2015). Managing refractory epilepsy. Epilepsia, 41, 293–298. doi:  10.1586/ern.09.114.
Riley, J. D., Franklin, D. L., & Choi, V. (2010). Altered white matter integrity in temporal lobe epilepsy: Association with cognitive and clinical profiles. Epilepsia, 51, 536–545. doi: 10.1111/j.1528-1167.
Schwarz, M., Pauli, E., & Stefan, H. (2004). Benennstörungen nach epilepsiechirurgischen Eingriffen im sprachdominanten Temporallappen. Epilepsia, 3, 77–81.
Smith, M. L., & Puka, K. (2016). Epilepsy and cognition. journal of Nerology, 1, 281–301. doi: 10.1007/978-3-319.
Tang, V., Warden, J., Cullen, N., & Rutledge, E. (2007). Topiramate in traumatic brain injury: Adverse effects on cognitive function. The Journal of Head Trauma Rehabilitain, 22, 409–410. doi: 10.1097/01.HTR.0000300236.
Thompson, P. J., & Duncan, J. S. (2005). Cognitive Decline in Severe Intractable Epilepsy. Epilepsy Research, 46, 1780–1787. doi: 10.1111/j.1528-1167.
Valente, K. D., Rzezak, P., & Moschetta, S. P. (2016). Delineating behavioral and cognitive phenotypes in juvenile myoclonic epilepsy: Are we missing the forest for the trees? Epilepsy Behavior, 54,95–99. doi: 10.1016/j.yebeh1022.
Van Rijckevorsel, K. (2006). Cognitive problems related to epilepsy syndromes, especially malignant epilepsies. Seizure, 15, 227–234. doi: 10.1016/j.3456.
Vecht, C., Duran-Peña, A., & Houillier, C. (2017). Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations. Neurooncology, 133, 603–607. doi: 10.1007/s11060-017-2473-1.
Voltzenlogel, V., Hirsch, E., & Vignal, J. P. (2015). Preserved anterograde and remote memory in drug-responsive temporal lobe epileptic patients. Epilepsy Research, 115, 126–132. doi: 10.1016/j.eplepsyres06006.
Wang, W.H.. Liou, H. H., & Chen, C. C. (2001). Neuropsychological performance and seizure-related risk factors in patients with temporal lobe epilepsy: A retrospective cross-sectional study. Epilepsy Behavior, 22, 728-734. doi: 10.1016/j.yebe0838.
Journal of Research in Psychopathology
Volume 1, Issue 1
2020
Pages 10-15

Files

Share

How to cite

Statistics